New Approach May Yield Vaccine Against Alzheimer’s

Alzheimer’s disease (AD) was first described at the turn of the twentieth century by Dr. Alois Alzheimer. Upon performing an autopsy on a woman with a combination of memory loss, unusual and unpredictable behavior, and difficulty with language, he found two distinct sets of brain abnormalities. The first were unusual clumps of tissue; the second were tangles of fibers. Today, we know the former as amyloid plaques, a buildup and clustering of amyloid proteins, and the latter we call tau (or neurofibrillary) tangles, an abnormal connection of tau proteins into long, tangled fibers.

One of the many aspects of Alzheimer’s research has been the effort to develop a vaccine to prevent it. This area of research has been unsuccessful. Until now.

In a paper, published in the journal Alzheimer’s Research & Therapy, researchers describe a new approach to Alzheimer’s vaccination. This approach is fundamentally from previous approaches. Before, Alzheimer’s vaccines were developed in a similar way to other vaccines: antibodies were developed against amyloid and tau proteins, and then injected as vaccines.

However, vaccines come with side and treats them as a threat to the body, attacking them. This attack, or “rejection” of the antibodies, led to a variety of physical reactions, including inflammation at the injection site. While inflammation of the skin around in injection site is considered a “mild” reaction, the proposed Alzheimer’s vaccines caused inflammation in the brain, a far more serious reaction. in the brain.

Rather than introducing antibodies, the new approach sparks the person’s own immune system to develop its own defenses against buildup of both amyloid plaques and tau tangles. . Since the antibodies are “home-grown,” the body does not perceive them as foreign, and does not react to them. The vaccine reduces amyloid plaques by 40 percent, and tau tangles by 50 percent. And it does so without causing the brain inflammation that had doomed previous efforts.

So far, the vaccine has only been tested in animals, so there is still much research that must be done before a clinical trial in humans is possible. But in the fight against Alzheimer’s, the potential for a vaccine is a tremendously exciting prospect.

Until Alzheimer’s can be eradicated, the best possible treatment is compassionate, dedicated care, offered by specialists in the field At Hamilton Grove Healthcare and Rehabilitation Center, in Hamilton, NJ, we are experts in handling all levels of cognitive impairment, from mild cognitive impairment to Alzheimer’s and other dementias.

We have created a unique environment and care program specifically designed to address the needs of this population. Our Alzheimer’s Unit is situated in a separate, secure wing to ensure the safety and well-being of our residents. It offers a structured daily routine, mind-stimulating activities, excellent social interaction, with optimal patient independence in a calm and soothing atmosphere.

Moreover, all our care programs are designed specifically to meet the unique needs and interests of seniors and long-term care patients. We emphasize restorative care, maximizing each patient’s potential to regain and maintain function and mobility.

We foster an environment that is cheerful and enthusiastic, so residents truly relish and appreciate life.

Our outstanding Social Services team works hard to ensure that every resident thrives socially, emotionally, and spiritually.

We promote a culture of independence, crucial for emotional, social, and physical health. Residents are encouraged to choose their activity and meal preferences, and to perform tasks and activities as self-sufficiently as possible.

We carefully select, train and re-train our wonderful caregivers, who are especially sensitive to the needs of our long-term care patients. They treat residents with love, compassion, and dignity.


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